The development of web application for variability detection in the DNA sequence

Jasmin Avdić (2018) The development of web application for variability detection in the DNA sequence. EngD thesis.

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Abstract

This diploma thesis presents a development of web application for variability detection in the DNA sequence called Amplicode 2018. DNA consists of four nucleotides adenine (A), cytosine (C), guanine (G) and thymine (T) which are interconnected into sequence. The phenotype level differences are related to genetic code at the genotype level. Sequences with different variations can determine particular attributes, for example height, hair colour, pigmentation of the iris, predispositions to specific diseases, etc. Web application Amplicode 2018 enables detection of sequence variations within a gene of choice using different open source tools. The entire tool and parameter selection is carried out using the user-friendly website, that can be used by users with limited knowledge of Linux operating system, commands and switches of open source tools. The end result is consistently provided in the same format, regardless the various intermediate steps. It offers the ability to analyse the quality of the detection of variations with respect to different tools and helps user in further wet lab decisions.

Item Type:

Thesis (EngD thesis)

Keywords:

alignment, Bash, DNA, DNA variations, PHP, Python, nucleotide, sequence, web application

Number of Pages:

Language of Content:

Slovenian

Mentor / Comentors:

Name and Surname	ID	Function
viš. pred. dr. Igor Rožanc	278	Mentor
prof. dr. Kristina Gruden		Comentor

Link to COBISS:

http://www.cobiss.si/scripts/cobiss?command=search&base=51012&select=(ID=1537937091)

Institution:

University of Ljubljana

Department:

Faculty of Computer and Information Science

Item ID:

4218

Date Deposited:

13 Sep 2018 17:36

Last Modified:

01 Oct 2018 08:58

URI:

http://eprints.fri.uni-lj.si/id/eprint/4218

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