Peter Juvan and Janez Demsar and Gad Shaulsky and Blaz Zupan (2005) GenePath: from mutations to genetic networks and back. Nucleic Acids Res, 33 (Web Se). W749-W752.
Abstract
GenePath is a web-based application for the analysis of mutant-based experiments and synthesis of genetic networks. Here, we introduce GenePath and describe a number of new approaches, including conflict resolution, handling cyclic pathways, confidence level assignment, what-if analysis and new experiment proposal. We illustrate the key concepts using data from a study of adhesion genes in Dictyostelium discoideum and show that GenePath discovered genetic interactions that were ignored in the original publication. GenePath is available at http://www.genepath.org/genepath2.
| Item Type: | Article |
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| Keywords: | epistasis, gene networks, mutations, abduction, logic |
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| Institution: | University of Ljubljana |
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| Department: | Faculty of Computer and Information Science |
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| Divisions: | Faculty of Computer and Information Science > Artificial Intelligence Laboratory |
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| Item ID: | 895 |
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| Date Deposited: | 19 Aug 2009 13:56 |
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| Last Modified: | 05 Dec 2013 15:11 |
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| URI: | http://eprints.fri.uni-lj.si/id/eprint/895 |
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