Peter Juvan and Janez Demsar and Gad Shaulsky and Blaz Zupan (2005) GenePath: from mutations to genetic networks and back. Nucleic Acids Res, 33 (Web Se). W749-W752.
GenePath is a web-based application for the analysis of mutant-based experiments and synthesis of genetic networks. Here, we introduce GenePath and describe a number of new approaches, including conflict resolution, handling cyclic pathways, confidence level assignment, what-if analysis and new experiment proposal. We illustrate the key concepts using data from a study of adhesion genes in Dictyostelium discoideum and show that GenePath discovered genetic interactions that were ignored in the original publication. GenePath is available at http://www.genepath.org/genepath2.
|Item Type: ||Article|
|Keywords: ||epistasis, gene networks, mutations, abduction, logic|
|Institution: ||University of Ljubljana|
|Department: ||Faculty of Computer and Information Science|
|Divisions: ||Faculty of Computer and Information Science > Artificial Intelligence Laboratory|
|Item ID: ||895|
|Date Deposited: ||19 Aug 2009 13:56|
|Last Modified: ||13 Aug 2011 00:35|
Actions (login required)