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Epistasis analysis with global transcriptional phenotypes

Nancy Van Driessche and Janez Demsar and Ezgi O Booth and Paul Hill and Peter Juvan and Blaz Zupan and Adam Kuspa and Gad Shaulsky (2005) Epistasis analysis with global transcriptional phenotypes. Nature Genetics, 37 (5). pp. 471-477.

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    Classical epistasis analysis can determine the order of function of genes in pathways using morphological, biochemical and other phenotypes. It requires knowledge of the pathway's phenotypic output and a variety of experimental expertise and so is unsuitable for genome-scale analysis. Here we used microarray profiles of mutants as phenotypes for epistasis analysis. Considering genes that regulate activity of protein kinase A in Dictyostelium, we identified known and unknown epistatic relationships and reconstructed a genetic network with microarray phenotypes alone. This work shows that microarray data can provide a uniform, quantitative tool for large-scale genetic network analysis.

    Item Type: Article
    Keywords: epistasis, gene networks, phenotypes, morphology
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    http://www.cobiss.si/scripts/cobiss?command=search&base=50070&select=(id=4712532)Alternative location
    Institution: University of Ljubljana
    Department: Faculty of Computer and Information Science
    Divisions: Faculty of Computer and Information Science > Artificial Intelligence Laboratory
    Item ID: 894
    Date Deposited: 19 Aug 2009 13:50
    Last Modified: 05 Dec 2013 15:22
    URI: http://eprints.fri.uni-lj.si/id/eprint/894

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