Iva Blažina and Bogdan Pavlič and Ivan Župič (1996) . Prešeren awards for students.

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Abstract

Cardiac ischemia is a disease caused by insufficient blood supply in the heart muscle region, usually due to partially occluded coronary artery. Frequent ischemia symptom is angina pectoris, typical chest pain. Ischemia may also occur asymptomaticly. Ischemia can cause myocardial infarction, which leads to one half of all deaths from heart disease. Ischemia is associated with transient ST segment changes of electrocardiogram (ECG). We tested a hypothesis that different physiological mechanisms associated with cardiac ischemia, cause different temporal patterns of ST-segment level change. Ambulatory (Holter) records of the European Society of Cardiology ST-T database were used as test material. Two extrema groups of records were studied: the salvo pattern group and one-episode pattern group. We characterized time and frequency-domain heart rate function changes, and frequency of appearence of ventricular ectopic beats sorrounding the ischemic episodes. All results support our specific hypothesis that the salvos reflect coronary vasoconstrictions or vasospasms due to psyhological stress or occluded vessel, and that the isolated episodes reflect ischemia due to increased physical activity.

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